Missiles blew up part of a compound Wednesday in northwest Pakistan, killing three people - including one woman - a government official said.
The latest suspected U.S. drone strike also injured two children, military officers said.
Militants lived in the compound, but so did civilians, the officers said.
An official with the Pakistani Ministry of Foreign Affairs, not authorized to speak on the record, condemned today's attack. Previously, the ministry has said it lodged a complaint with the U.S. Embassy in Islamabad about drone strikes in Pakistani territory on October 10 and 11. The ministry called those "a clear violation of international law and Pakistan's sovereignty."
There's growing fury over the U.S. pounding of areas known to be home to al Qaeda operatives, mainly in tribal zones along Pakistan's border with Afghanistan. A recent independent study said hundreds of civilians, including 176 children, have been killed in the attacks over the last eight years.
U.S. President Barack Obama and his challenger Mitt Romney seem to largely see eye-to-eye on the issue. CNN national security analyst Peter Bergen notes that most Americans "are comfortable with the muscular use of CIA drones against al Qaeda in Pakistan."
The United States rarely comments on the strikes.