Police in Anson seized a suitcase and a cooler full of marijuana after a routine traffic stop early Thursday morning.
Chase Beaulieu and Logan Mac Wade have been taken into custody and charged with possession of marijuana.
The two were driving from California, according to authorities, and may have been under the influence of the illegal drug.
The marijuana totaled about 12 pounds and had a street value estimated at about $40,000.
Police said the pair may have been on their way to Clyde.